Prexasertib (LY2606368) 2HCl
产品编号: DC7993
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应用领域
Prexasertib dihydrochloride (LY2606368 dihydrochloride) 是一种有效的，选择性的，ATP 竞争性的 Chk1 抑制剂，Ki 值为 0.9 nM，对 CHK1 和 CHK2 的 IC50 值分别为 <1 nM 和 8 nM。
| Cas No.: |
1234015-54-3 |
| 名称: |
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| 别名: |
LY 2606368,LY-2606368 |
| SMILES: |
NCCCOC(C=CC=C1OC)=C1C2=CC(NC3=NC=C(C#N)N=C3)=NN2.[H]Cl.[H]Cl |
| 分子式: |
C18H21Cl2N7O2 |
| 分子量: |
438.31 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
LY2606368 2Hcl is a potent and selective ATP competitive inhibitor(IC50=1.5 nM in SW1990 cell) of the Chk1 protein kinase.LY2606368 alone significantly inhibited the cell proliferation in a variety of pancreatic cell lines (SW1990, SU86.86, Bx-PC3, AsPC-1 |
| Kinase Assay: |
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| Cell Assay: |
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| References: |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_2060_DC7993_1234015-54-3 |
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COA
| LOT NO. |
DOWNLOAD |
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