BAF312 (Siponimod)
产品编号: DC7694
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应用领域
Siponimod (BAF-312)是有效，选择性的 鞘氨醇-1-磷酸 (S1P) 受体调节剂。 它对S1P1和S1P5受体的选择性高于S1P2，S1P3和S1P4 (EC50 分别为0.39，0.98，10,000，1,000和750 nM)。
| Cas No.: |
1230487-00-9 |
| 名称: |
1-[[4-[(E)-N-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-C-methylcarbonimidoyl]-2-ethylphenyl]methyl]azetidine-3-carboxylic acid |
| 别名: |
Siponimod; Siponimod [INN]; BAF-312, BAF 312 |
| SMILES: |
N(CC1=CC=C(/C(=N/OCC2=CC=C(C3CCCCC3)C(C(F)(F)F)=C2)/C)C=C1CC)1CC(C(O)=O)C1 |
| 分子式: |
C29H35F3N2O3 |
| 分子量: |
516.59501 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
BAF312 is a potent and selective agonist of S1P with EC50 value of 0.39nM for S1P1 receptors and 0.98nM for S1P5 receptors, respectively .
BAF312 has shown >1000-fold selectivity for S1P1 versus S1P2, S1P3 and S1P4 receptors . In vitro metabolism studies |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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