| References: |
In SH-SY5Y cells, AZD3839 efficiently decreases the Aβ40 levels with IC50 of 4.8 nM, and decreases the formation of sAPPβ with IC50 of 16.7 nM. AZD3839 also decreases the Aβ40 levels secreted from C57BL/6 mouse primary cortical neurons, N2A cells, and Dunkin-Hartley guinea pig primary cortical neurons with IC50 values of 50.9, 32.2, and 24.8 nM, respectively. AZD3839 causes in vitro BACE1 inhibition in the cell assay with IC50 value of 16.7 nM. In C57BL/6 mice, AZD3839 (69 mg/kg, p.o.) causes a dose- and time-dependent reduction of plasma and brain Aβ. In guinea pig and non-human primates, AZD3839 also inhibits Aβ generation. For the detailed information of AZD3839, the solubility of AZD3839 in water, the solubility of AZD3839 in DMSO, the solubility of AZD3839 in PBS buffer, the animal experiment (test) of AZD3839, the cell expriment (test) of AZD3839, the in vivo, in vitro and clinical trial test of AZD3839, the EC50, IC50,and affinity,of AZD3839, For the detailed information of AZD3839, the solubility of AZD3839 in water, the solubility of AZD3839 in DMSO, the solubility of AZD3839 in PBS buffer, the animal experiment (test) of AZD3839, the cell expriment (test) of AZD3839, the in vivo, in vitro and clinical trial test of AZD3839, the EC50, IC50,and affinity,of AZD3839, Please contact DC Chemicals. |
