Rigosertib

产品编号: DC7265 Featured
Rigosertib
结构式
1225497-78-8
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应用领域
Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM; shows 30-fold greater selectivity against PLK2 and no activity to PLK3.
Cas No.: 1225497-78-8
名称: 2-[2-methoxy-5-[[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonylmethyl]anilino]aceticacid
别名: ON-01910; ON01910; ON 01910
SMILES: COC1=C(C=C(C=C1)CS(=O)(=O)C=CC2=C(C=C(C=C2OC)OC)OC)NCC(=O)[O-].[Na+]
分子式: C21H24NNaO8S
分子量: 473.47
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Rigosertib is non-ATP-competitive inhibitor to PLK1 with IC50 of 9 nM. Rigosertib also exhibits inhibition against PLK2, PDGFR, Flt1, BCR-ABL, Fyn, Src, and CDK1, with IC50 of 18-260 nM. Rigosertib shows cell killing activity against 94 different tumor ce
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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MSDS_1653_DC7265_1225497-78-8
COA
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产品编号 产品名称 应用领域
DC8598 PLK1 inhibitor GSK461364 GSK461364 是选择性,可逆,ATP竞争性的 PLK1 抑制剂,Ki 值为 2.2 nM。
DC7265 Rigosertib Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM; shows 30-fold greater selectivity against PLK2 and no activity to PLK3.
DC7187 Volasertib(BI6727) Volasertib 是一种高效的 Polo-like 激酶 1 (PLK1) 抑制剂,IC50 值为 0.87 nM,同时能够抑制 PLK2 和 PLK3,IC50 值分别为 5 和 56 nM。
DC7083 Bi 2536 BI 2536 是 PLK1 和 BRD4 的双抑制剂,IC50 分别为 0.83 和 25 nM。BI-2536 抑制 IFNB (IFN-β,干扰素 β) 基因转录。