INK-128
产品编号: DC7171
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应用领域
Sapanisertib (INK-128; MLN0128; TAK-228) 是一种口服有效的 ATP依赖性的 mTOR1/2 抑制剂，抑制 mTOR 激酶的IC50 值为 1 nM。
| Cas No.: |
1224844-38-5 |
| 名称: |
3-(2-aminobenzo[d]oxazol-5-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| 别名: |
INK 128; INK128 |
| SMILES: |
CC(C)N1C2=C(C(=N1)C3=CC4=C(C=C3)OC(=N4)N)C(=NC=N2)N |
| 分子式: |
C15H15N7O |
| 分子量: |
309.33 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vitro: |
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| References: |
INK 128 exhibits an enzymatic inhibition activity against mTOR and more than 100-fold selectivity to PI3K kinases. As TORC1/2 inhibitor, INK 128 inhibits both the phosphorylation of S6 and 4EBP1, the downstream substrates of TORC1, and selectively inhibi |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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询盘
