APY29
产品编号: DC7358
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应用领域
APY29 是 ATP 竞争性抑制剂，一种特异性的 IRE1α 别构调节剂，通过结合到 ATP 结合口袋来抑制 IRE1α 的自主磷酸化，IC50 值为 280 nM。APY29 也可以变构激活 IRE1α 相邻 RNase 域。
| Cas No.: |
1216665-49-4 |
| 名称: |
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| 别名: |
APY 29; APY-29 |
| SMILES: |
C1CC1C2=CC(=NN2)NC3=NC(=NC=C3)NC4=CC5=C(C=C4)N=CN5 |
| 分子式: |
C17H16N8 |
| 分子量: |
332.36 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vivo: |
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| In Vitro: |
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| References: |
APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.
IC50 value: 280 nM
Target: IRE1α
APY29 is a highly potent and selective small molecule modulator of IRE1α. Under endoplasmic |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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询盘
