| References: |
BI-847325 shows growth-inhibitory effects on BRAF-mutant and vemurafenib-resistant melanoma cells with IC50 ranging from 0.3 nM to 2 μM, and prevents colony formation in six BRAF-mutant melanoma cell lines. BI-847325 also induces apoptosis by reducing Mcl-1 expression. In mice bearing 1205Lu and 1205LuR xenografts, BI-847325 (75 mg/kg, p.o.) causes significant tumor suppression without significant alteration in the body weights. For the detailed information of BI-847325, the solubility of BI-847325 in water, the solubility of BI-847325 in DMSO, the solubility of BI-847325 in PBS buffer, the animal experiment (test) of BI-847325, the cell expriment (test) of BI-847325, the in vivo, in vitro and clinical trial test of BI-847325, the EC50, IC50,and affinity,of BI-847325, For the detailed information of BI-847325, the solubility of BI-847325 in water, the solubility of BI-847325 in DMSO, the solubility of BI-847325 in PBS buffer, the animal experiment (test) of BI-847325, the cell expriment (test) of BI-847325, the in vivo, in vitro and clinical trial test of BI-847325, the EC50, IC50,and affinity,of BI-847325, Please contact DC Chemicals. |
