| References: |
In IFN-γ–treated human HeLa cells, INCB024360 potently inhibits kynurenine production. INCB024360 also promotes T and natural killer (NK)-cell growth, increases IFN-gamma production, and reduces conversion to regulatory T (T(reg))-like cells. [1INCB024360 (100 mg/kg, p.o.), via IDO1 inhibition, suppresses kyn generation and tumor growth in immunocompetent, but not immunodeficient, mice. In mice bearing CT26 colon carcinoma, INCB024360 (100 mg/kg, p.o.) also inhibits the growth of IDO-expressing tumors by reducing kynurenine. For the detailed information of Epacadostat (INCB024360), the solubility of Epacadostat (INCB024360) in water, the solubility of Epacadostat (INCB024360) in DMSO, the solubility of Epacadostat (INCB024360) in PBS buffer, the animal experiment (test) of Epacadostat (INCB024360), the cell expriment (test) of Epacadostat (INCB024360), the in vivo, in vitro and clinical trial test of Epacadostat (INCB024360), the EC50, IC50,and affinity,of Epacadostat (INCB024360), For the detailed information of Epacadostat (INCB024360), the solubility of Epacadostat (INCB024360) in water, the solubility of Epacadostat (INCB024360) in DMSO, the solubility of Epacadostat (INCB024360) in PBS buffer, the animal experiment (test) of Epacadostat (INCB024360), the cell expriment (test) of Epacadostat (INCB024360), the in vivo, in vitro and clinical trial test of Epacadostat (INCB024360), the EC50, IC50,and affinity,of Epacadostat (INCB024360), Please contact DC Chemicals. |
