LY2811376
产品编号: DC5180
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应用领域
LY2811376 是一种可口服的，非肽段的 β-secretase (BACE1) 抑制剂，IC50 值为 239 nM-249 nM，能够降低 Aβ 蛋白的分泌，EC50 值为 300 nM。
| Cas No.: |
1194044-20-6 |
| 名称: |
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| 别名: |
LY 2811376;LY-2811376 |
| SMILES: |
C[C@]1(CCSC(=N1)N)C2=C(C=C(C(=C2)C3=CN=CN=C3)F)F |
| 分子式: |
C15H14F2N4S |
| 分子量: |
320.36 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vitro: |
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| References: |
LY2811376 is a BACE1 inhibitor with marked Ab-lowering effects in animal models. Oral administration of LY2811376 to PDAPP mice produced dose-dependent reductions in brain Abeta, C99 and sAPPb. Brain Abeta levels were decreased 50% relative to vehicle-tre |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_1462_DC5180_1194044-20-6 |
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COA
| LOT NO. |
DOWNLOAD |
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