| References: |
CEP-32496 is a highly potent inhibitor of BRAF(V600E/WT) and c-Raf with Kd of 14 nM/36 nM and 39 nM, also potent to Abl-1, c-Kit, Ret, PDGFRβ and VEGFR2, respectively; insignificant affinity for MEK-1, MEK-2, ERK-1 and ERK-2.CEP-32496 is a potent BRAF inhibitor in an in vitro binding assay for mutated BRAF(V600E) (K(d) BRAF(V600E) = 14 nM) and in a mitogen-activated protein (MAP)/extracellular signal-regulated (ER) kinase (MEK) phosphorylation (pMEK) inhibition assay in human melanoma (A375) and colorectal cancer (Colo-205) cell lines (IC(50) = 78 and 60 nmol/L). In vitro, CEP-32496 has multikinase binding activity at other cancer targets of interest; however, it exhibits selective cellular cytotoxicity for BRAF(V600E) versus wild-type cells. For the detailed information of CEP-32496, the solubility of CEP-32496 in water, the solubility of CEP-32496 in DMSO, the solubility of CEP-32496 in PBS buffer, the animal experiment (test) of CEP-32496, the cell expriment (test) of CEP-32496, the in vivo, in vitro and clinical trial test of CEP-32496, the EC50, IC50,and affinity,of CEP-32496, For the detailed information of CEP-32496, the solubility of CEP-32496 in water, the solubility of CEP-32496 in DMSO, the solubility of CEP-32496 in PBS buffer, the animal experiment (test) of CEP-32496, the cell expriment (test) of CEP-32496, the in vivo, in vitro and clinical trial test of CEP-32496, the EC50, IC50,and affinity,of CEP-32496, Please contact DC Chemicals. |
