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N-(p-Amylcinnamoyl) anthranilic Acid (ACA)

产品编号: DC12492 Featured
N-(p-Amylcinnamoyl) anthranilic Acid (ACA)
结构式
110683-10-8
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中国地区超过5000个高品质化合物库存
应用领域
N-(p-amylcinnamoyl) Anthranilic Acid (ACA) 是一种广谱磷脂酶A2 (PLA2) 的抑制剂，TRP 通道的阻滞剂。N-(p-amylcinnamoyl) Anthranilic Acid (ACA) 也是一种有效的钙离子激活氯通道 (calcium-activated chloride channels) 的可逆抑制剂，具有治疗心律失常的潜能。
化学性质生物活性化合物的使用COA & MSDS相关产品产品说明书
Cas No.: 110683-10-8
名称:
别名:
SMILES: CCCCCC1=CC=C(C=C1)/C=C/C(=O)NC2=CC=CC=C2C(=O)O
分子式: C21H23NO3
分子量: 337.4
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: N-(p-Amylcinnamoyl) anthranilic Acid (ACA), a cell permeable inhibitor of PLA2, has been reported to inhibit α-ketoisocaproic acid and glyceraldehyde-induced insulin secretion, as well as glucose-induced insulin secretion. Additionally, by inhibiting PLA2, ACA consequentially suppresses glucose-induced arachidonic acid formation in cells. Furthermore, research has shown ACA to modulate the activity of different transient receptor potential channels. In particular, ACA's blocking ability of diacylglycerol-activated TRP channels is of special interest since it offers the opportunity to interfere with receptor-induced Ca2+-dependent signaling processes in vascular smooth muscle cells and platelets.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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