Apoptozole

产品编号: DC10122 Featured
Apoptozole
结构式
1054543-47-3
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中国地区超过5000个高品质化合物库存
应用领域
Apoptozole (Apoptosis Activator VII) 是 Hsc70 和 Hsp70 的 ATPase 结构域抑制剂,可诱导凋亡,Kd 值分别为 0.21 和 0.14 μM。
Cas No.: 1054543-47-3
名称:
别名:
SMILES: COC1=CC=C(C=C1)C2=C(N(C(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)CC4=CC=C(C=C4)C(=O)N)C5=CC=C(C=C5)OC
分子式: C33H25F6N3O3
分子量: 625.56
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Apoptozole is an inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 μM) that acts by blocking its ATPase activity. In vitro: Apoptozole binds HSP70 but not other types of heat shock proteins and induces caspase-dependent apoptosis. Apoptozole does not affect interactions of HSP70 with ASK1, JNK, BAX, and AIF. Apoptozole aggregates under aqueous conditions. In vivo: Animal studies indicate that Az treatment retards tumor growth in a xenograft mouse model without affecting mouse viability.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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