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Description of MK-4827: MK-4827 is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. The PARP family of proteins detect and repair single strand DNA breaks by the base-excision repair (BER) pathway. The specific PARP family member target For PARP inhibitor MK4827 is unknown. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
For the detailed information about the solubility of MK-4827 in water, the solubility of MK-4827 in DMSO, the solubility of MK-4827 in PBS buffer, the animal experiment（test） of MK-4827, the in vivo,in vitro and clinical trial test of MK-4827, the cell experiment（test） of MK-4827, the IC50, EC50 and Affinity of MK-4827 , please contact DC Chemicals. |
