TAK-733
产品编号: DC7308
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应用领域
TAK-733 是一种有效的选择性 MEK 抑制剂，IC50 为 3.2 nM。
| Cas No.: |
1035555-63-5 |
| 名称: |
(R)-3-(2,3-dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione |
| 别名: |
TAK733; TAK 733 |
| SMILES: |
C1N(C[C@H](O)CO)C(=O)C2C(NC3=CC=C(I)C=C3F)=C(F)C(=O)N(C)C=2N=1 |
| 分子式: |
C17H15F2In4O4 |
| 分子量: |
504.23 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vitro: |
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| References: |
TAK-733 is highly potent and selective MEK allosteric site inhibitor with IC50 of 3.2 nM. TAK-733 shows potent enzymatic and cell activity with an EC50 of 1.9 nM against ERK phosphorylation in cells. TAK-733 demonstrates broad antitumor activity in mouse |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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询盘
