| Cas No.: | 100872-83-1 |
| 名称: | |
| 别名: | ML346，ML 346 |
| SMILES: | COC1=CC=C(C=C1)C=CC=C2C(=O)NC(=O)NC2=O |
| 分子式: | C14H12N2O4 |
| 分子量: | 272.26 |
| 纯度: | |
| 保存条件: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | |
| In Vivo: | |
| In Vitro: | |
| References: | ML346 is a novel activator of Hsp70 with EC50 of 4600 nM in HeLa cell toxicity assay. in vitro: ML346 has good chemical stability, significantly high water solubility, is not reactive with excess glutathione, and is cell permeable. The probe ML346 will help elucidate roles for activation of Hsp70 and HSF-1 in the prevention and progression of cancers, cellular aging, and metabolic and neurodegenerative disorders. ML346 is a novel modulator of proteostasis for protein conformational diseases. in vivo: ML346 activates transcription of the Hsp70 promoter and suppresses aggregation of poly-glutamines in a C. elegans model, suggesting the probe has efficacy in modifying protein aggregation and associated toxicity. ML346 induces HSF-1-dependent chaperone expression and restores protein folding in conformational disease models. |
| Kinase Assay: | |
| Cell Assay: | |
| Animal Administration: | |
| References: |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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