BMS-687453
产品编号: DC9252
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应用领域
BMS-687453 是一种有效的，选择性的 PPARα 激动剂，对人 PPARα 的 EC50 和 IC50 分别为 10 nM 和 260 nM；较弱地抑制 PPARγ 的活性，EC50 和 IC50 值分别为 4100 nM 和 >15000 nM。
| Cas No.: |
1000998-59-3 |
| 名称: |
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| 别名: |
BMS-687453，BMS687453，BMS 687453 |
| SMILES: |
C(O)(=O)CN(CC1=CC=CC(OCC2=C(C)OC(C3=CC=C(Cl)C=C3)=N2)=C1)C(OC)=O |
| 分子式: |
C22H21ClN2O6 |
| 分子量: |
444.865 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vitro: |
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| References: |
BMS687453 is a potent and selective peroxisome proliferator activated receptor (PPAR) α agonist, with an EC50 of 10 nM for human PPARα and ∼410-fold selectivity vs human PPARγ in PPAR-GAL4 transactivation assays. Similar potencies and selectivity were also observed in the full length receptor co-transfection assays. BMS687453 has negligible cross-reactivity against a panel of human nuclear hormone receptors including PPARδ. BMS687453 demonstrated an excellent pharmacological and safety profile in preclinical studies and thus was chosen as a development candidate for the treatment of atherosclerosis and dyslipidemia. |
| Kinase Assay: |
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| Animal Administration: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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