2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
PCI-34051 is a specific inhibitor of HDAC8 with IC50 of 10 nM, with >200-fold selectivity over the other HDAC isoforms.
IC50 Value: 10 nM
Target: HDAC8
in vitro: PCI-34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias, but not in other hematopoietic or solid tumor lines. Unlike broad-spectrum HDAC inhibitors, PCI-34051 does not cause detectable histone or tubulin acetylation. Cells defective in T-cell receptor signaling were still sensitive to PCI-34051-induced apoptosis, whereas a phospholipase C-gamma1 (PLCgamma1)-defective line was resistant. HDAC8-inhibitor specifically induces cell death in T-cell-derived lines, which is caspase dependent
For the detailed information about the solubility of PCI-34051 in water, the solubility of PCI-34051 in DMSO, the solubility of PCI-34051 in PBS buffer, the animal experiment（test） of PCI-34051,the in vivo,in vitro and clinical trial test of PCI-34051,the cell experiment（test） of PCI-34051,the IC50, EC50 and Affinity of PCI-34051, please contact DC Chemicals.
