2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
SLx-2119 selectively inhibits activity of human ROCK2 (IC50 = 105 nM), while effects on human ROCK1 in this cell-free system were minimal (IC50 = 24 μM). SLx-2119 at 40 μM induced significant down-regulations of Tsp-1 and CTGF mRNA levels. SLx-2119 induced a significant down-regulation of Tsp-1 transcripts in HMVEC and PASMC only and induced a down-regulation of CTGF transcripts, although non-significant, in all 3 cell types(HMVEC, PASMC, and NHDF). SLx-2119 induced a down-regulation of the genes COL1A1, COL1A2, COL3A1, and COL5A2 in PASMC, an up-regulation of the gene MMP1 in PASMC, a down-regulation of the gene COL3A1 in NHDF, and an up-regulation of the genes COL7A1, COL4A2, MMP1, MMP3, MMP14, and MMP17 in NHDF For the detailed information of SLx-2119(KD-025), the solubility of SLx-2119(KD-025) in water, the solubility of SLx-2119(KD-025) in DMSO, the solubility of SLx-2119(KD-025) in PBS buffer, the animal experiment (test) of SLx-2119(KD-025), the cell expriment (test) of SLx-2119(KD-025), the in vivo, in vitro and clinical trial test of SLx-2119(KD-025), the EC50, IC50,and affinity,of SLx-2119(KD-025), For the detailed information of SLx-2119(KD-025), the solubility of SLx-2119(KD-025) in water, the solubility of SLx-2119(KD-025) in DMSO, the solubility of SLx-2119(KD-025) in PBS buffer, the animal experiment (test) of SLx-2119(KD-025), the cell expriment (test) of SLx-2119(KD-025), the in vivo, in vitro and clinical trial test of SLx-2119(KD-025), the EC50, IC50,and affinity,of SLx-2119(KD-025), Please contact DC Chemicals.
