2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
Akt Inhibitor VIII is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity (IC50 = 58 nM, 210 nM, and 2.12 μM; respectively). It does not exhibit any inhibitory effect against pleckstrin homology (PH) domain-lacking Akts, AGC family kinases, PKA, PKC or SGK. Akt Inhibitor VIII prevails over Akt1/Akt2-mediated resistance to chemotherapeutics in tumor cells and has been shown to block basal and stimulated phosphorylation/activation of Akt1/Akt2 in cultured cells and in mice. For the detailed information of Akt Inhibitor VIII, the solubility of Akt Inhibitor VIII in water, the solubility of Akt Inhibitor VIII in DMSO, the solubility of Akt Inhibitor VIII in PBS buffer, the animal experiment (test) of Akt Inhibitor VIII, the cell expriment (test) of Akt Inhibitor VIII, the in vivo, in vitro and clinical trial test of Akt Inhibitor VIII, the EC50, IC50,and affinity,of Akt Inhibitor VIII, For the detailed information of Akt Inhibitor VIII, the solubility of Akt Inhibitor VIII in water, the solubility of Akt Inhibitor VIII in DMSO, the solubility of Akt Inhibitor VIII in PBS buffer, the animal experiment (test) of Akt Inhibitor VIII, the cell expriment (test) of Akt Inhibitor VIII, the in vivo, in vitro and clinical trial test of Akt Inhibitor VIII, the EC50, IC50,and affinity,of Akt Inhibitor VIII, Please contact DC Chemicals.
