2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
Description of Sirolimus: Sirolimus is a natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with immunosuppressant properties. In cells, sirolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This results in inhibition of T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (IL-2, IL-4, and IL-15) stimulation and inhibition of antibody production. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
For the detailed information about the solubility of Rapamycin (Sirolimus) in water, the solubility of Rapamycin (Sirolimus) in DMSO, the solubility of Rapamycin (Sirolimus) in PBS buffer, the animal experiment（test） of Rapamycin (Sirolimus),the in vivo,in vitro and clinical trial test of Rapamycin (Sirolimus),the cell experiment（test） of Rapamycin (Sirolimus),the IC50, EC50 and Affinity of Rapamycin (Sirolimus), please contact DC Chemicals.
