2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
PRIMA-1MET was tested using 3 HMCLs that expressed either a wild-type protein (XG6), or a TP53R175H mutant protein previously reported to be reactivated by PRIMA-1Met (OPM2), or no p53 protein (JJN3). PRIMA-1Met (LD50 value) did not induce p21 expression but did induce strong expression of Noxa in HMCLs, regardless of the p53 expression or status. Of note, the expression of p53 either mutated or wild-type, became undetectable after PRIMA-1Met treatment. PRIMA-1Met induced apoptosis as revealed by the cleavage of caspases 2 and 3, and PARP.
