2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
TGN 020 is a thiadiazole derivative which has been studied as an antitumoragent. Furthermore, N-(1,3,4-Thiadiazolyl)nicotinamide is an inhibitor of Aquaporin 4 (AQP4), the most abundant water channel in brain. Aquaporins (AQPs) are water channels required for maintaining fluid homeostasis and enabling water movement across barrier membranes, but can enhance pathological cellular volume changes and cause edema in injury states. Pretreatment with the AQP4 inhibitor N-(1,3,4-Thiadiazolyl)nicotinamide significantly reduced the volume of brain edema associated with ischemic injury in a mouse model of focal cerebral ischemia.
