2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
NAV 2729 (NAV2729) is a novel, direct and selective small molecule inhibitor of small GTPase ARF6 with IC50 of 1.5 uM in nucleotide exchange assays; shows no inhibitory effects for all other human ARF family members, as well as other small GTPases, such as RhoA, Rac1, H-Ras, and Cdc42 (IC50>50 uM); inhibits all known signaling pathways downstream of oncogenic GNAQ in uveal melanoma cells, including PLC/PKC, Rho/Rac, YAP, and β-catenin; reduces uveal melanoma cell proliferation and tumorigenesis in mouse models.
