SN-6 is a selective Na+/Ca2+exchange (NCX) inhibitor, displaying some selectivity for NCX1. IC50 values are 2.9, 16 and 8.6 μM for inhibition of intracellular Na+-dependent Ca2+ uptake by cells expressing NCX1, NCX2 and NCX3 respectively. SN-6 has some affinity for mACh receptors (IC50 = 18 μM) but minimal activity against NCKX2 and various receptors and ion channels (IC50 > 30 μM). Preferentially blocks Ca2+ influx mode and is more selective for NCX isoforms than KB-R7943. This compound acts as an anti-ischemic, potently protecting against hypoxia-induced renal tubular cell damage (IC50 = 0.63 μM).
