Ciliobrevin A(HPI4) 产品说明书 Chemicals
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产品编号 DC9875
名称 Ciliobrevin A(HPI4)

化学性质

CAS 302803-72-1
分子式 C17H9CL2N3O2
分子量 358.18
存储条件 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

生物活性

Description
In Vivo
In Vitro

化合物的使用

Kinase Assay
Cell Assay
Animal Administration

参考文献


HPI-4 is a Hedgehog pathway inhibitor and ciliogenesis inhibitor. The Hedgehog (HH) signaling pathway is targeted for anti-cancer therapeutics and HPI-4 blocks Sonic hedgehog (Shh)-induced hedgehog pathway activation (IC50 = 7 μM) downstream of Smo. It also inhibits cytoplasmic AAA+ ATPase dynein-dependent microtubule gliding and ATPase activity.
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