2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
TUG-1375 (TUG1375, TUG 1375) is a potent, selective free fatty acid receptor 2 (FFA2/GPR43) agonist with β-arrestin-2 pEC50 of 6.1 and cAMP pEC50 of 7.11; also shows activity on the murine FFA2 orthologue (pEC50=6.44 in the cAMP assay), displays no significant agonist or antagonist response in FFA1 (GPR40) or FFA4 (GPR120), or in nuclear receptors PPARα, PPARγ, PPARδ, LXRα or LXRβ; induces migration of human neutrophils and inhibits lipolysis in murine adipocytes.
