2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
ANA-12 is a potent and selective TrkB antagonist with anxiolytic and antidepressant activity in mice.ANA-12 prevented activation of the receptor by BDNF with a high potency. ANA-12 showed direct and selective binding to TrkB and inhibited processes downstream of TrkB without altering TrkA and TrkC functions. Saturation binding studies with TrkBECD-Fc showed that ANA-12 binds TrkBECD-Fc with a Kd of 12 μM . The selective TrkB (tropomyosin-receptor-kinase) antagonist ANA-12 reduced OIH when given one or seven days after cessation of morphine For the detailed information of ANA-12, the solubility of ANA-12 in water, the solubility of ANA-12 in DMSO, the solubility of ANA-12 in PBS buffer, the animal experiment (test) of ANA-12, the cell expriment (test) of ANA-12, the in vivo, in vitro and clinical trial test of ANA-12, the EC50, IC50,and affinity,of ANA-12, Please contact DC Chemicals.
