2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
BAY-850 is a potent, isoform selective, cellularly active ATAD2 bromodomain inhibitor with binding IC50 of 166 nM in TR-FRET assay; shows no inhibitory activity in a panel of 354 kinases and only modest effects on a few GPCRs; displaces a tetra-acetylated H4 peptide with an IC50 of 22 nM, and the tetra-acetylated peptides with IC50 of 115 nM; pecifically induces ATAD2 bromodomain dimerization and prevents interactions with acetylated histones in vitro, as well as with chromatin in cells.
