2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
Protein phosphorylation is a prevalent and ubiquitous
mechanism of regulation. Kinases are popular
drug targets, but identifying selective phosphatase
inhibitors has been challenging.Raphin1 inhibits the recombinant R15BPP1c
holoenzyme, but not the closely related
R15A-PP1c, by interfering with substrate recruitment.Raphin1 is orally available and crosses the blood-brain
barrier.Raphin1 inhibits PPP1R15B, transiently lowers translation,
and improves proteostasis.Raphin1 decreases deficits in a mouse model of
Huntington’s disease
