2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
CHS-828 is a pyridyl cyanoguanidine anti-tumor agent that has been identified as a competitive inhibitor of Nampt as well as an inhibitor of NF-κB pathway activity.CHS-828 has potent cytotoxic effects in human breast (IC50 = 7.3 nM) and lung cancer (IC50 = 0.5 nM) cells both in vitro and in vivo.In nude mice bearing human tumor xenografts, CHS-828, at 20-50 mg/kg/day, inhibits the growth of MCF-7 breast cancer tumors and induces regression of NYH small cell lung cancer tumors. For the detailed information of GMX1778(CHS-828) , the solubility of GMX1778(CHS-828) in water, the solubility of GMX1778(CHS-828) in DMSO, the solubility of GMX1778(CHS-828) in PBS buffer, the animal experiment (test) of GMX1778(CHS-828) , the cell expriment (test) of GMX1778(CHS-828) , the in vivo, in vitro and clinical trial test of GMX1778(CHS-828) , the EC50, IC50,and affinity,of GMX1778(CHS-828) , For the detailed information of GMX1778(CHS-828) , the solubility of GMX1778(CHS-828) in water, the solubility of GMX1778(CHS-828) in DMSO, the solubility of GMX1778(CHS-828) in PBS buffer, the animal experiment (test) of GMX1778(CHS-828) , the cell expriment (test) of GMX1778(CHS-828) , the in vivo, in vitro and clinical trial test of GMX1778(CHS-828) , the EC50, IC50,and affinity,of GMX1778(CHS-828) , Please contact DC Chemicals.
