2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
Anavex 2-73 is a small molecule that activates the sigma-1 receptor, which is known to modulate cellular processes relevant to neurodegeneration. Specifically, Anavex 2-73 is thought to help restore cellular balance by targeting protein misfolding (when proteins fail to fold correctly, into a normal configuration, they do not work as intended), oxidative stress (which damages cells due oxygen molecules with free radicals, or unpaired electrons), mitochondrial dysfunction, inflammation, and cellular stress.The sigma-1 receptor is a small transmembrane protein, a stress reducing and survival protein, mainly located on the endoplasmic reticulum membrane of cells. This receptor is also present on the surface of some nerve cells and multiple other central nervous system cell types and tissues. As sigma-1 receptors are present in various sites, different physiological and pathological processes may be influenced by treatment with Anavex 2-73.
The brain of a person with Alzheimer’s has fewer sigma-1 receptors than healthy people of the same age. Therefore the induction or activation of these receptors could improve the clinical symptoms of AD and protect against neurologic changes. Researchers believe that this activation may be achieved by the regulation of calcium and the reduction of oxidative stress.
