2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
LY3009120, also known as DP-4978, is potent and selective pan-RAF inhibitor with potential anticancer activity. LY3009120 showed activities against BRaf or Ras mutant tumor cells. LY3009120 binds to ARaf, BRaf and CRaf isoforms with similar affinity in cells with activating mutations of BRaf or KRas. LY3009120 induces minimal paradoxical pathway activation in NRas or KRas mutant cells. LY3009120 inhibits MEK phosphorylation and cell proliferation in vitro, and exhibits anti-tumor activity in multiple xenograft models carrying mutations in BRaf, NRas or KRas. LY3009120 is a potentially best-in-class inhibitor of three Raf isoforms and Raf dimer, with activity against tumor cells with BRaf, NRas or KRas mutations, as well as melanoma cells with acquired resistance to current BRaf therapies. These unique features support investigation of LY3009120 in clinical studies. For the detailed information of LY3009120, the solubility of LY3009120 in water, the solubility of LY3009120 in DMSO, the solubility of LY3009120 in PBS buffer, the animal experiment (test) of LY3009120, the cell expriment (test) of LY3009120, the in vivo, in vitro and clinical trial test of LY3009120, the EC50, IC50,and affinity,of LY3009120, For the detailed information of LY3009120, the solubility of LY3009120 in water, the solubility of LY3009120 in DMSO, the solubility of LY3009120 in PBS buffer, the animal experiment (test) of LY3009120, the cell expriment (test) of LY3009120, the in vivo, in vitro and clinical trial test of LY3009120, the EC50, IC50,and affinity,of LY3009120, Please contact DC Chemicals.
