2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
TAS-120 (Futibatinib, TAS120) is a highly potent, selective, irreversible pan-FGFR inhibitor with IC50 of 0.9 nM for wt FGFR2; inhibits cancer cell growth in vitro and shows promising activity in human xenografts of FGFR mutation-bearing tumours; TAS-120 inhibits mutant and wild-type FGFR2 with similar IC50 (wild-type FGFR2, 0.9 nM; V565I 1.3 nM; N550H, 3.6 nM; E566G, 2.4 nM) and has shown efficacy in FGFR inhibitor-resistant cell lines.
