UE2343(Xanamem) 产品说明书 Chemicals
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产品编号 DC11783
名称 UE2343(Xanamem)

化学性质

CAS 1346013-80-6
分子式 C19H19N5O2S
分子量 381.454
存储条件 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

生物活性

Description CAS NO.：1346013-80-6
Product Name：(5-(1H-pyrazol-4-yl)thiophen-3-yl)((1R,3r,5S)-3-hydroxy-3-(pyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-8-yl)methanone
Synonyms：UE-2343;UE 2343;Xanamem
EINEC:
Molecular Formula：C19H19N5O2S
Molecular Weight
In Vivo
In Vitro

化合物的使用

Kinase Assay
Cell Assay
Animal Administration

参考文献


UE2343 (UE-2343, Xanamem) is a potent, orally bioavailable, brain penetrant 11β-HSD1 inhibitor with IC50 of 24 nM in cell-free assays, with no activity for isozyme 11β-HSD2; displays a superior preclinical profile for further development, and shows potential for cognitive impairment in early Alzheimer's disease (AD).
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