Tyrphostin AG-555 产品说明书 Chemicals
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产品编号 DC10468
名称 Tyrphostin AG-555

化学性质

CAS 133550-34-2
分子式 C19H18N2O3
分子量 322.36
存储条件 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

生物活性

Description
In Vivo
In Vitro

化合物的使用

Kinase Assay
Cell Assay
Animal Administration

参考文献


AG 555 is a potent EGFR (epidermal growth factor receptor) kinase inhibitor (IC50 = 0.7 μM) that displays 50-fold and >140-fold selectivity over ErbB2 and insulin receptor kinase respectively. AG 555 induces G1 growth arrest selectively in transformed cells (IC50 values are 6.4 and 9.4 μM in HPV16-immortalized and normal keratinocytes respectively).
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