2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
(+)-WIN 55,212-2 (mesylate) is a potent aminoalkylindole cannabinoid (CB) receptor agonist with a Ki of 62.3 and 3.3 nM For human recombinant CB1 and CB2 receptors, respectively.1 In primary cultures of rat cerebral cortex neurons, (+)-WIN 55,212-2 (mesylate) (0.01-100 nM) increases extracellular glutamate levels, displaying a bell-shaped concentration-response curve.2 This effect at a concentration of 1 nM was fully counteracted by SR141716A (10 nM), by decreasing Ca2+ concentrations below 0.2 mM, and by the IP3 receptor antagonist xestospongin C at 1 µM. (+)-WIN 55,212-2 (mesylate) induces release of the proinflammatory neuropeptide CGRP from trigeminal ganglion (TG) neurons in a calcium-dependent manner with an EC50 of 26 µM.3 In addition, (+)-WIN 55,212-2 (mesylate)-evoked CGRP release is not stereospecific, as the CB receptor-inactive enantiomer (+)-WIN 55,212-3 also stimulates CGRP exocytosis. For the detailed information about the solubility of WIN 55212-2 mesylate in water, the solubility of WIN 55212-2 mesylate in DMSO, the solubility of WIN 55212-2 mesylate in PBS buffer, the animal experiment（test） of WIN 55212-2 mesylate,the in vivo,in vitro and clinical trial test of WIN 55212-2 mesylate,the cell experiment（test） of WIN 55212-2 mesylate,the IC50, EC50 and Affinity of WIN 55212-2 mesylate, please contact DC Chemicals.
