2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
PQR-620 (PQR620) is a novel potent and selective, brain penetrant inhibitor of mTORC1/2; displays >1000-fold selectivity towards mTOR over PI3Kα in enzymatic binding assays; demonstrates inhibition of protein kinase B (pSer473) and ribosomal protein S6 (pSer235/236) phosphorylation with IC50 of 0.2 uM and 0.1 uM, respectively; shows anti-tumor effects in vitro and in vivo.
