Venetoclax(ABT-199) 产品说明书 Chemicals
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产品编号 DC2002
名称 Venetoclax(ABT-199)

化学性质

CAS 1257044-40-8
分子式 C45H50CLN7O7S
分子量 868.44
存储条件 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

生物活性

Description
In Vivo
In Vitro

化合物的使用

Kinase Assay
Cell Assay
Animal Administration

参考文献


ABT-199 is a potent and selective inhibitor of B-cell lymphoma-2 (BCL-2) family proteins, currently in clinical trials. It is an engineered version of ABT-263 (Navitoclax) but with much better selectivity. It selectively hits Bcl-2 while ABT-263 hits both Bcl-2 and Bcl-xl. For the detailed information about the solubility of ABT-199 (GDC-0199) in water, the solubility of ABT-199 (GDC-0199) in DMSO, the solubility of ABT-199 (GDC-0199) in PBS buffer, the animal experiment(test) of ABT-199 (GDC-0199),the in vivo,in vitro and clinical trial test of ABT-199 (GDC-0199),the cell experiment(test) of ABT-199 (GDC-0199),the IC50, EC50 and Affinity of ABT-199 (GDC-0199), please contact DC Chemicals.
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