2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
Potent TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively). Exhibits >350-fold selectivity for TRPM8 over TRPV4, TRPV1 and TRPA1. Reduces HSC3 and HSC4 oral squamous carcinoma cell migration and invasion in vitro. Also attenuates icilin-induced wet dog shakes in rats. Orally active. For the detailed information of RQ-00203078, the solubility of RQ-00203078 in water, the solubility of RQ-00203078 in DMSO, the solubility of RQ-00203078 in PBS buffer, the animal experiment (test) of RQ-00203078, the cell expriment (test) of RQ-00203078, the in vivo, in vitro and clinical trial test of RQ-00203078, the EC50, IC50,and affinity,of RQ-00203078, For the detailed information of RQ-00203078, the solubility of RQ-00203078 in water, the solubility of RQ-00203078 in DMSO, the solubility of RQ-00203078 in PBS buffer, the animal experiment (test) of RQ-00203078, the cell expriment (test) of RQ-00203078, the in vivo, in vitro and clinical trial test of RQ-00203078, the EC50, IC50,and affinity,of RQ-00203078, Please contact DC Chemicals.
