Clofarabine(Clolar; Clofarex) inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase. IC50 Value: 65 nM Target: in vitro: Clofarabine is a second generation purine nucleoside analog with antineoplastic activity. It is phosphorylated intracellularly, which inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase, resulting in inhibition of DNA repair and synthesis of DNA and RNA. This nucleoside analog also disrupts mitochondrial function and membrane integrity, resulting in the release of pre-apoptotic factors, including cytochrome C and apoptotic-inducing factor, which activate apoptosis. in vivo: Clofarabine is used for treating relapsed or refractory acute lymphoblastic leukaemia (ALL) in children, after at least two other types of treatment have failed. For the detailed information of Clofarabine, the solubility of Clofarabine in water, the solubility of Clofarabine in DMSO, the solubility of Clofarabine in PBS buffer, the animal experiment（test） (test) of Clofarabine, the cell expriment (test) of Clofarabine, the in vivo, in vitro and clinical trial test of Clofarabine, the EC50, IC50,and Affinity of Clofarabine,, please contact DC Chemicals.
