2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
Targocil, a novel antibiotic against MRSA. The effects of Targocil has been shown that in murine model of endophthalmitis, and also tested the efficacies of Targocil for a panel of MSSA and MRSA isolates from cases of bacterial keratitis. It was found that Targocil is more effective than vancomycin in blocking intracellular S. aureus growth. Moreover, resistant mutants that arise upon selection with these compounds are highly attenuated and show reduced epithelial cell binding and invasion. Targocil is an inhibitor of TarG, the transmembrane component of the two component ABC transporter that exports WTAs from the cytoplasm to the external surface of the bacterial membrane where they are attached to peptidoglycan. Targocil has minimally inhibitory concentration (MIC) of 0.3 uM. Targocil shows inhibitory activities against both methicillin-sensitive and methicillin-resistant S. aureus strains. The acute toxicity of Targocil has been tested: doses of 75 mg/kg administered via tail vein injection caused no adverse effects in mice after 24 h.
