2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
Dorzagliatin is a glucose-lowering drug with a novel mechanism of action. It acts as an activator of the enzyme glucokinase which is expressed chiefly in the pancreas and liver. The glucokinase activators are a novel class of glucose-lowering drugs which are still in development. The enzyme glucokinase acts as a glucose sensor at the pancreas, and as a glucose processor in the liver. It increase the responsiveness of the beta cell, i.e, the ability to regulate insulin secretion in response to minor changes in ambient glycemia. It also facilitates processing of glucose in the liver, and suppresses hepatic gluconeogenesis.
