2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
NSC 23766 is a specific inhibitor of the binding and activation of Rac GTPase. In vitro studies have shown that NSC 23766 inhibits Rac 1 binding and activation via Rac-specific GEF Trio or Tiam 1 without altering RhoA or CDC42 binding or activation. Membrane type 1-matrix metalloproteinases (MT-1MMP) expression in CB CD34+ cells has been reported to decrease in the presence of NSC 23766. Silveta compressa investigations indicate that NSC 23766 depolarizes endomembrane cycling, altered polar adhesive secretion, and tip growth.
