Defactinib (VS-6063, PF-04554878) 产品说明书 Chemicals
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产品编号 DC7695
名称 Defactinib (VS-6063, PF-04554878)

化学性质

CAS 1073154-85-4
分子式 C20H21F3N8O3S
分子量 510.5
存储条件 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

生物活性

Description
In Vivo
In Vitro

化合物的使用

Kinase Assay
Cell Assay
Animal Administration

参考文献


Defactinib is a potent, selective, and orally active FAK inhibitor with demonstrated tolerability and preliminary clinical activity working as a single agent as well as in combination with paclitaxel.Defactinib inhibited FAK phosphorylation at the Tyr397
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