2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
Fostamatinib sodium is an orally available disodium salt of the Syk kinase inhibitor fostamatinib with potential anti-inflammatory and immunomodulating activities. Fostamatinib inhibits Syk kinase-mediated IgG Fc gamma receptor signaling, resulting in inhibition of the activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage. Syk kinase, widely expressed in hematopoietic cells, is a nonreceptor tyrosine kinase that is involved in coupling activated immunoreceptors to signal downstream events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. For the detailed information about the solubility of R788 disodium (Fostamatinib) in water, the solubility of R788 disodium (Fostamatinib) in DMSO, the solubility of R788 disodium (Fostamatinib) in PBS buffer, the animal experiment（test） of R788 disodium (Fostamatinib),the in vivo,in vitro and clinical trial test of R788 disodium (Fostamatinib),the cell experiment（test） of R788 disodium (Fostamatinib),the IC50, EC50 and Affinity of R788 disodium (Fostamatinib), please contact DC Chemicals.
